References Library

TOPIC: Is Liver Cirrhosis reversible?

• Reversal of liver cirrhosis: current evidence and expectations
Young Kul Jung and Hyung Joon Yim

Korean J Intern Med 2017;32:213-228 https://doi.org/10.3904/kjim.2016.268
http://kjim.org/upload/kjim-2016-268.pdf

• Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
Iredale JP1, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ.

J Clin Invest. 1998 Aug 1;102(3):538-49.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508915/

• Is liver fibrosis reversible?
Benyon RC1, Iredale JP

Gut. 2000 Apr;46(4):443-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1727904



TOPIC: Chronic Liver Disease (CLD) disrupts the metabolism of Patients with CLD. A review of Metabolomic Studies

• The metabolomic window into hepatobiliary disease.
Beyoğlu D, Idle JR

J Hepatol. 2013 Oct;59(4):842-58. doi: 10.1016/j.jhep.2013.05.030. Epub 2013 May 25
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095886/



TOPIC: NASH Studies

• NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.
GC, van Rooyen D, Gan L, Chitturi S.

Gut Liver. 2012;6:149–171
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343154/



TOPIC: Cirrhosis Studies

• The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis.
Wiegand J, Berg T.

Dtsch Arztebl Int. 2013;110:85–91.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583179/



TOPIC: NASH and other CLD disrupt Phospholipid and Bile Acid Synthesis

• Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.
Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ.

Hepatology. 2012;56:118–129.
https://www.ncbi.nlm.nih.gov/pubmed/22290395

• Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway.
Kharbanda KK, Mailliard ME, Baldwin CR, Beckenhauer HC, Sorrell MF, Tuma DJ

J Hepatol. 2007 Feb;46(2):314-21. Epub 2006 Oct 26.
https://www.ncbi.nlm.nih.gov/pubmed/17156888



TOPIC: NASH disrupts SAMe synthesis, Methionine cycling and Glutathione Production

• S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility.
Anstee QM, Day CP.

J Hepatol. 2012 Nov;57(5):1097-109. doi: 10.1016/j.jhep.2012.04.041. Epub 2012 May
http://www.journal-of-hepatology.eu/article/S0168-8278(12)00409-6/fulltext

• Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine.
Mazen Noureddin, José M Mato, and Shelly C Lu

Exp Biol Med (Maywood). 2015 Jun; 240(6): 809–820.
https://www.ncbi.nlm.nih.gov/pubmed/25873078



TOPIC: NASH disrupts One-Carbon Methylation including the Folic Acid Cycle

• Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine.
Kalhan SC, Edmison J, Marczewski S, Dasarathy S, Gruca LL, Bennett C, Duenas C, Lopez R.

Clin Sci (Lond). 2011 Aug;121(4):179-89. doi: 10.1042/CS20110060.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097472/

• Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation.
Cordero P, Campion J, Milagro FI, Martinez JA.

Mol Genet Metab. 2013 Nov;110(3):388-95. doi: 10.1016/j.ymgme.2013.08.022. Epub 2013 Sep 17.
https://www.ncbi.nlm.nih.gov/pubmed/24084163



TOPIC: CS Lieber Studies

• DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction.
Cao Q, Mak KM, Lieber CS.

Liver Int. 2006 Mar;26(2):221-31
https://www.ncbi.nlm.nih.gov/pubmed/16448461

• Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years.
Lieber CS.

Rocz Akad Med Bialymst. 2005;50:7-20. Review.
https://www.ncbi.nlm.nih.gov/pubmed/16363067

• DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1.
Xu Y, Leo MA, Lieber CS

Alcohol Alcohol. 2005 May-Jun;40(3):172-5. Epub 2005 Mar 7
https://www.ncbi.nlm.nih.gov/pubmed/15753073

• New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments.
Lieber CS.

Curr Gastroenterol Rep. 2004 Feb;6(1):60-5. Review
https://www.ncbi.nlm.nih.gov/pubmed/14720455

• I. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease: effects on drinking behavior by nurse/physician teams.
Lieber CS, Weiss DG, Groszmann R, Paronetto F, Schenker S; Veterans Affairs Cooperative Study 391 Group.

Alcohol Clin Exp Res. 2003 Nov;27(11):1757-64.
https://www.ncbi.nlm.nih.gov/pubmed/14634491

• II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease.
Lieber CS, Weiss DG, Groszmann R, Paronetto F, Schenker S; Veterans Affairs Cooperative Study 391 Group.

Alcohol Clin Exp Res. 2003 Nov;27(11):1765-72.
https://www.ncbi.nlm.nih.gov/pubmed/14634492

• Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine.
Aleynik SI, Lieber CS.

Alcohol Alcohol. 2003 May-Jun;38(3):208-12.
https://www.ncbi.nlm.nih.gov/pubmed/12711653

• Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats.
Cao Q, Mak KM, Lieber CS.

Biochem Biophys Res Commun. 2002 Dec 6;299(3):459-64.
https://www.ncbi.nlm.nih.gov/pubmed/12445823

• DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells.
Cao Q, Mak KM, Lieber CS.

Am J Physiol Gastrointest Liver Physiol. 2002 Nov;283(5):G1051-61.
https://www.ncbi.nlm.nih.gov/pubmed/12381518

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