HepAssure

HepAssure Medical Food for Patients with Chronic Liver Disease (CLD)
■ HepAssure is a non-drug formula that consists of 32 ingredients that are classified as GRAS (Generally Regarded As Safe) by the FDA. (Please CLICK HERE to see the list of ingredients)
■ Ingredients found in HepAssure are substances (metabolites) involved in normal human metabolism.
■ Chronic Liver Disease (CLD) alters or up-regulates certain metabolic pathways in Patients with CLD.
■ HepAssure provides metabolites that are affected by these CLD-altered metabolic pathways.
■ Studies show that patients with Chronic Liver Disease (CLD) require more of these metabolites in their diet than normal healthy people.
■ HepAssure Medical Food for Patients with CLD is designed to provide metabolites in order to satisfy the distinctive nutritional requirements of patients with CLD.

HepAssure Medical Food and Chronic Liver Disease

There are many different types of Chronic Liver Disease (CLD).

Non-Alcoholic Fatty Liver Disease/Non-Alcoholic SteatoHepatitis (NAFLD/NASH)
Alcohol Liver Disease (ALD)
Hepatitis C (HCV)
Hepatitis B (HBV)
Hemochromatosis
Wilson's Disease
Primary Biliary Cholangitis (PBC)

… and other forms of CLD all cause liver injury and chronic inflammation which leads progressive liver fibrosis/cirrhosis in CLD patients.

CLD disrupts the metabolism of the CLD patient. These metabolic alterations create an increased demand for certain metabolites that normal healthy people do not experience. These unique metabolic demands create new distinctive nutritional requirements for patients with CLD. CLD patients cannot satisfy these new nutritional requirements with regular diet modification alone.

A medical food for CLD patients must strategically identify, coordinate and supply both the proper amount and proper balance of metabolites necessary to fulfill the new distinctive nutritional requirements of CLD patients. Disrupted CLD-associated metabolic pathways (1,6) are listed below:

  • Dis-regulation of phospholipid metabolism and membrane phospholipid reallocation
  • Dis-regulation of cholesterol and bile acid homeostasis
  • Increased storage of cytosolic triglycerides and fatty acids accompanied with altered β-oxidation of fatty acids,
  • A shift from aerobic respiration to anaerobic glycolysis,
  • Increased utilization of thiol-containing metabolites including increased glutathione/cysteine cycling, increased SAM/SAH/methionine cycling and increased one-carbon methylation metabolism

The CLD-related metabolic alterations listed above involve up-regulation and increased cycling of metabolites involved in the following biosynthetic pathways (1,2,3,4,5,6):

  • The GSH pathway as well as other GSH-linked antioxidant systems (1,5)
  • Both the PEMT and the CDP-Choline Phosphatidylcholine (PC) biosynthetic pathways (1,6)
  • The SAM/Methionine cycle (1,2, 3, 6)
  • One-carbon metabolism (including folic acid cycle) (4)
  • Amino acid metabolism (1)

HepAssure medical food satisfies the new distinctive nutritional requirements for Patients with CLD by supplying metabolites involved in CLD-altered metabolic pathways in appropriate quantities and proportion.

What is a Medical Food?

A medical food is a non-drug formula that may contain only ingredients that are found on the FDA's GRAS [ READ MORE ]

HonorHealth IRB Human Clinical Trial

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HepAssure Medical Food and Chronic Liver Disease

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HepAssure Ingredients

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